Based on what I just went thru/learned while getting my scanner to work today, I'll suggest something, but with no guarantees.
Check the file /etc/sane.d/<drivername.conf> where <drivername> might be 'ep' 'or 'epson' in your case. Make sure the line(s) identifying your scanner, port, driver are/is correct.
If there is a specific port named there, it may help to change the post to * (an asterisk) so the scanner front-end will scan for it and locate it.
I'm using Slackware, but hopefully the filepaths for the SANE files are the same/very similar to mine.
Best of luck
