I installed skype on ubunto and after the first restart it appears the error 5: input/output error, I cant more run synaptic!!! (The same problem as you remember on last version of Ubunto) the hard disc begins to make sounds and a red forbidden sign appears on top close to internet connection sign. When I tried to uninstall skype directly from terminal I got this error:

mojdeh@mojdeh-laptop:~$ sudo apt-get --purge remove skype
[sudo] password for mojdeh:
Reading package lists... Error!
E: Read error - read (5: Input/output error)
E: The package lists or status file could not be parsed or opened.

Would you please help me to solve this problem?
Thanks

Sounds like a dying disk. Get a new hard disk and reinstall.