You can upgrade from Mandrake 7.2 to newer versions of Mandrake. Going to another distro, however, will be much more problematic. You can keep your home stuff (providing you have a seperate partition for /home) quite easily, but other stuff will likely not work... for example, if I remember correctly, RH and SuSE put more stuff in /opt that Mandrake ever does, so your PATH would be incorrect and some things wouldn't run.
I suppose, if you had a lot of time on your hands you could update every package you have with a newer version from RH or SuSE's collection (rpm -Uvh for update), but I don't know how well this would work as most things will rely on libraries, etc, that would also need updating.
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