I think what may be the problem, is that u are running it in the ntfs partition, because ntfs is read-only.
Try copying all the files into your ~/.wine/drive_c/Program\ Files/Diablo\ II folder
be sure to add write access to the save folder
And then, before running it, be sure to cd into that folder and then run wine
If that doesn't work, look at :
http://www.latte.ca/D2LOD/
It worked great for me, even though i did it a bit differently: instead of using that start package thing, I just copied the files from my windows partition, but then i still used the regestry entries from the latte.ca/d2lod site.
Everything works pretty nice, but i still have a couple problems. look at my post here (some quirks are quite comical):
http://www.linuxquestions.org/questi...hreadid=210027