Code:
nvidia-settings --load-config-only
Other than that, you should take a look at the documentation (which should be) in
/usr/share/doc/nvidia/README (search for "X Config Options"). There are
tons of things you can configure in the Xorg config file directly (
/etc/X11/xorg.conf or
/etc/X11/xorg.conf.d/20-nvidia.conf), many of which aren't available in the
nvidia-settings GUI.