I've had fewer problems with usb pendrives and usb hid devices in Linux than in Windows. At work, a salesman left behind some 1G usb drives. They don't work in XP or Win2000, but work in Linux. Right now, I'm using a Logitec wireless mouse. I used to use a Tascan wireless mouse before it went bad (got wet?). Both worked by just plugging in the transmitter.
If there are special features to the mouse, you may need some xorg.conf edits to fully utilize them but virtually any usb wheel mouse should work fine.
It is hard for people to chime in whether they use the same brand of mouse and usb pendrive if you don't indicate the brand & model.
P.S. I don't have any experience with bluetooth devices. Linux does have bluetooth support, but your wife may need to use here distro's configuration wizard, and may need to enable bluetooth in the netbooks bios.
Last edited by jschiwal; 12-27-2008 at 04:17 PM.