Are you getting any errors? What type of media are you referring to? What program are you using to open the media?
The issue I most often encounter is codec related issues, because Fedora does not by default install codecs that require a license.
To resolve, Google rpmfusion, setup the repositories on your Fedora yum, then you can search and install "gstreamer" plugins. Look for "good", "bad" and "ugly" - those are the ones I generally install and all my codec issues get resolved.