The mail server (on your computer) is asking the mail server from your ISP to do a relay for you. That ISP mail server is refusing (most ISP servers refuse to do relays now, as a spam prevention and also to save their bandwidth). This is not something you can fix on your computer, your ISP is denying you relays on purpose. Your ISP is simply telling you, "No, I won't do a relay for you."
Do you have your local email client configured to send mail through your local computer via Postfix, and then have Postfix contact your ISP to relay that email? You should have your email client contacting your ISP mail server directly, not via Postfix. If you really need to run a mail server daemon on your local computer, you need to find a different ISP who will do relays for you. Or pay the one you have more money to do so, if they will even do it at all.