if the route is associated with a certain device then the config file in
/etc/sysconfig for that device can have a GATEWAY= entry
but the easiest thing is to just put the route command you are using
at the bottom of a startup script
say
/etc/rc.d/init.d/rc
(different distros have way different converntions for this)
but somewhere you will find as apropriate
even at the bottom of
/etc/inittab will work i bet
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