If you have used the wine installer that guides you through the compilation process, rather than doing the standard './configure && make && make install' routine, wine should have already created the fake windows drives for you. They should be located at /home/username/.wine/drive_c, unless you've changed the default settings. If you had NOT used the wine installer, I have heard that running 'winecfg' creates those directories for you, though I did not try doing that on my own.
Moreover, all that the fake C: drive does for you is create directories to hold the windows dlls, so that when you run a program under wine, it can find these dlls the same way it would find them in windows. As far as installing and running windows programs, it is often a safer bet to copy over the entire program directory from a windows machine either through a LAN connection or by using the ntfs drivers if dual-booting. You don't need to copy it in the drive hierarchy created by wine, any directory will do. Just run it with 'wine winexec.exe' and it should work fine as long as the fake C: drive was setup during the install.
Unfortunately, my knowledge is not too extensive in this topic, so if you experience difficulty, you might want to google for a wine tutorial. Specific tutorials for installing your game in wine might be available too.
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