I joined this Forum just to say a massive thankyou to
TheRealGrogan for this solution. I've been tearing my hair out and getting extremely angry trying to get Fallout4 working on my Optimus graphics laptop under WINE.
It was actually working extremely well, I managed to get F4SE (a sort of master mod loader), all my mods (98 of them), and sound working perfectly on Fedora34 with WINE v6.11 (staging) - but only at a lousy 5fps using the Intel "GPU".
WINE simply refused to use my Nvidia card and I couldn't figure out why. Steam for Linux was using Nvidia, but it simply refused to load my mods (it couldn't find the Windows "AppData" folder for some unknown reason) which made it useless for me.
With some amazing luck, I tumbled on this page and followed
TheRealGrogan's advice and removed everything except nvidia_icd.json from /usr/share/vulkan/icd.d/ (...moved them to a backup folder) - and it worked
.
So many many thanks for your input.
Regards, Me
.