There's a difference here in terms of what's possible and what constitutes a good idea. if you use VMware server you can configure it to read a raw disk instead of a conventional vmdk image file. it's generally not recommended though, especially if you wish to boot directly to it as well. Linux will in the main be more tolerant to being used this way as compared to windows (ever swapped a drive into a different windows machine? spends half an hour installing new south bridge drivers etc...). so you can do it, but you're likely to come unstuck at some point i'd expect. you could do a smaller version though and use your /home partitino (assuming you have one) across both partitions, which will give you the same desktop, same configuration files etc... whch should be fine if it's virtually the same distro.
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