I think inkscape can get you part way there...
I just tried inkscape a few days ago and it was an easy move from Fireworks.
I'm not sure what your needs are.
I saw that the Gimp has an ability to make an image map, which is essential for my web design.
I like Krita. It has promise but a long ways to go. I Love the UI compared to Gimp.
Mohtech
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