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postfix is an MTA (mail transfer agent) which is a different thing. A typical webmail (like squirrelmail) interfaces with an imap server (like dovecot) and an MTA (like postfix).
I believe you can configure postfix with webmin, but mailservers are generally more granular that suits pretty gui interfaces (plus most mail servers don't use guis anyway).
I would look into Citadel, http://www.citadel.org/. Works out of the box most of the time, provides virtual users or host-based users, gui configuration, webmail, groupware, chat, calendar, and it is a nice collaboration environment. Spamassassin and clamav anti-virus can be added in if needed. It is very easy to setup. Postfix and others are great mail servers but require extensive work to gain the same end results as Citadel, and in the end you will have a much more cohesive setup using Citadel.
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