in..../etc/X11, you'll find the xf86config file...you can edit that as root, and it will only affect your mouse, and keep all the rest of your settings as they are right now. you need to edit it as root though...
i'm not sure what mouse you're using, so i can't really say how to edit it...but with my logitech usb mouse, this is my info from the XF86Config file...
Section "InputDevice"
Driver "mouse"
Identifier "Mouse[1]"
Option "Buttons" "5"
Option "Device" "/dev/mouse"
Option "Name" "Autodetection"
Option "Protocol" "imps/2"
Option "Vendor" "Sysp"
Option "ZAxisMapping" "4 5"
EndSection
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