Hey, this should be an easy one.
(Famous last words.....)
Open up your XF86Config file (don't know what distro you're running, but it's likely /etc/X11/XF86Config or possibly /etc/X11/XF86Config-4 )
Add the line:
Option "ZAxisMapping" "4 5"
to your Input Device section for your mouse - that whole section for one of mice is below:#
# Pointer section
#
Section "InputDevice"
Identifier "Mouse0"
Driver "mouse"
Option "Protocol" "IMPS/2"
Option "Device" "/dev/psaux"
Option "ZAxisMapping" "4 5"
EndSection
Cheers!