I have installed knoppix 6.0.1 persistent to a usb flash drive. I am currently testing it on my laptop and have successfully installed the graphics driver for nVidia Geforce 7150m driver 180.51
All looks great until i restart and it doesnt work again. when i go to reinstall it, it says its already there, but when i open the nvidia-settings, it doesnt look the same as before. If i reinstall it, it works again, until i restart of course.

In case this is important, here is how i installed the driver in root terminal:
sudo apt-get install gcc make
init 3
cd /home/knoppix/Desktop
sh NVIDIA-Linux-x86-180.51-pkg1.run
(A series of questions come up asking to compile a kernel, etc.)
(install runs)
init 5

Works!

I am guessing that the new kernel needed for the driver that is installed is not being booted up on when knoppix restarts. I am just unsure as how I can make this kernel accessible at start up or how to start up this kernel again without reinstalling the driver

figured out a quick fix!
knoppix was replacing the nvidia xorg.conf on startup!
I could not figure out how to stop it from doing so, but once i figured this out, i made a script shell to replace the xorg.conf file, go to init 3, then back to init 5 and it seems to work perfectly.