Depending on your choice of distro, and your needs.
I use mainly 64bit distros. My everyday distro is Debian Sid AMD64, and I have very few problems. Firefox plugins are the only missing thing, but I dont really miss them. Gnash is a good replacement for Flash, but it is easy to install Adobe Flash.
Other distros are also good, like Fedora, Ubuntu, SuSe, etc.
You won't notice much difference between 32bit and 64bit for general purpose tasks, however you paid for 64bit so why only use 32 of them
--Ian