Hi everyone. I'm currently collecting (buying) parts for my first own computer build, and of course i'll install Gentoo Linux. Been playing around with Funtoo a lot, but mainly used Arch Linux the past few years combining with W10.
My hardware is a ASUS X99 Deluxe II with a i7 6900K and at least 64 GB of RAM and a ASUS GTX 1080 ti and a system drive M.2 960 PRO 1 TB. I believe compiling will be a lot faster than on my Intel i5 NUC (5th generation).
I had some trouble earlier installing on M.2 Nvme drives, but learned the hard way to remember activating Nvme support in kernel config ((Device Drivers -> <*> NVM Express block device and[*] Open-Channel SSD target support) Funtoos Debian Sources does not have this enabled by default))
Anyone out there using Gentoo Linux on brand new "enthusiast" hardware? Is there anything i need to be aware of? I know i'll have to blacklist nouveau during install and get the Nvidia driver installed before configuring X.

I think i'll give systemd a chance, being used to it in Arch Linux nowadays.

Hello and welcome to LQ.

Sounds like you are on your way to a linux box.

This post might be moved to intro forum. I can't but gentoo mod may.

64 GB of RAM ... what for? Will you run a hundred virtual machines concurrently? Normal Gentoo desktop computer will never use that much RAM. My desktop is fully up with less than 110 MB of RAM utilized. Granted, it is nice to have 8 GB, then you can use tmpfs for compiling.
You do not need to blacklist anything. Just when you configure your kernel follow Gentoo nVidia wiki. Same goes for "configuring X", there is nothing to configure, just a four-line xorg.conf is needed to load the blob, see the wiki.

Thanks for your answer. Well 64 GB im swapping a lot already when editing 4K video as it is with my current 32 GB. I'll go with 128GB (it's almost the same price around 1000$ so it doesnt matter really. But will 64GB or more harm anything in Gentoo? In that case I'll sticj around with Arch Linux.

More RAM is always good. For video editing, you will definitely make use of it.

No amount of RAM will harm in any way. As for limits, all distros run the same kernel so they all have the same capabilities. Only the architecture you use will be relevant here. You just need to make sure you use an amd64 boot media to be able to compile and set up a 64 bits (amd64) Gentoo system (on a 32 bits x86 kernel most of your RAM will just not be addressable).

The only downside of having plenty of RAM is that the time needed to wake up from hibernation will be a bit higher, but that has nothing to do with the distro you use