OK; I've found the answer, and it looks like I can't.
@INC is set at configure time, and hard-coded into the /usr/bin/perl binary (although it seems that the Windows version derives at least one path from the installed location of the program).
@INC gets appended to by the PERLLIB and PERL5LIB environment variables, the -I<path> command-line option to perl, and the "use lib <path>;" perl instruction (which is the same as "BEGIN { unshift @INC, <path>; }")
Dynamicly changing the include path is on the wish-list, but isn't yet implemented.
You can change @INC by modifying /usr/bin/perl with a hex-editor, but that'll only work if you do
not want to make the paths longer or add new ones.
Source:
http://www.perlmonks.org/?node_id=9883