You can use the mpgsplit utility, part of the
mpgtx package. From the man page:
DESCRIPTION
mpgtx can split and join MPEG files in various ways. Three file types are currently handled (more to come): MPEG 1 Video files, MPEG 1/2 Audio files (mp1, mp2, and mp3), MPEG 1 System files (audio and video files), MPEG 2 Program files Experimental), MPEG 2 Transport files (demultiplex and info modes only). mpgtx is a GOP (Group of Pictures) based editor. This means that mpgtx cuts MPEG files on a Group Of Picture basis, not on a frame-by-frame basis. A typical GOP duration is about 0.5 sec (approx. 15 frames), limiting the maximum accuracy of mpgtx.