The work I do in Linux requires intensive mousing and I am experiencing a lot of pain in my wrist. I am looking for a device to replace my standard mouse with that might be better on my wrist and help reduce the amount of clicking I am doing. Any suggestions?

I've tried the Wacom tablet, but it's hard to get used too. (Too different compared to the standard mouse.) I am hoping to find some sort of 3D programmable input device. I've tried the following devices, but have not been able to get them to work with Linux. (Space Pilot Pro, Space Navigator, Contour Design Shuttle Pro V2, 3D mouse SpaceController, and Space Explorer)

Have you considered simply a higher-end mouse? I quite like the Wacom and found it an easy transition, but before that I was also doing like eight straight hours of point-and-clicking and so on a day, so my mouse was giving me problems, too. I got a Razer Death Adder even though I don't game, and it made a huge difference because of the shape, teflon feet, and super-sensitive laser eye and microswitches. Definitely makes for a much more pleasant experience- I use it every day at home. Just thought I'd mention that because it much more likely to be supported than the more esoteric tools you are mentioning.

I second the suggestion to consider looking at other mice.

I have two Gigaware mice (not a high-end brand by any means) that are slighly larger than average and are slightly sculpted on the sides. They are much more comfortable than traditional mice.

You might also consider external trackballs or trackpads. I don't like trackballs or trackpads myself, but that's me.

There are a number of posts on HID linux and they also have either on those pages or others info about game controller.

Might be time to consider voice or use other hand too. I switch between a track ball and mouse on each hand. I am right handed but I can easily use a trackball in my left hand.