Welcome to LQ.
I think you need to be more specific and clear as to what is needed. From what you said so far, I'm thinking authenticated encryption may be what you want:
https://en.wikipedia.org/wiki/Authenticated_encryption
However, unless it is a rewriteable disk, I doubt anyone can change the data in transit aside from switching the disk with another, but then that one won't decrypt unless it was encrypted with the same key.