I am unable to install or run Linux Mint 20 and many other Linux distros on a PC, unlike the many other PC's I have booted this particular OS onto, this is the first to have such a problem.

I followed all the steps to install it normally, Boot USB created, Secure boot off, UEFI Boot enabled. I was able to boot into the Grub menu and was met with the usual four options however all options (normal install, compatibility install, OEM install) did not work and instead resulted in the PC getting soft locked on the BIOS logo or black screen, except with compatibility simply getting stuck on a terminal error loop, common error messages are No "irq handler for vector" or various CPU not responding messages. This issue also extends to drives that have the OS already installed on them, so it's not an installation exclusive issue.

The issue extends to many other distributions that I have tested such as Manjaro, Kali, etc. All yield same issue, get to grub menu but can't advance passed it.

However, I am able to boot into Windows 10, this works with pre-installed drive and usb boot drives, the issue seems to be Linux exclusive, so this means the PC is functional, just acting funky.

I have attempted several fixes such as booting with the "nomodeset" fix or with rEFind boot manager, none work so far.

I have a theory that it may be a driver incompatibility or BIOS problem, but I do not know how to fix that if that were the issue, if a solution even exists as of now.

My PC's hardware is as follows:
CPU: Ryzen 5 5600x
GPU: ASUS Tuf gaming GTX 1650
Motherboard: MSI B450 A-PRO MAX
BIOS version: E7B86AMS.MD0 (released 2021-05-18)
Memory: Crucial Ballistix 32GB 3200mhz

Any help would be greatly appreciated.

I am running the same version of Mint, on multiple systems. However my motherboards are older. Donno if your BIOS has an option for legacy boot, but you could try that, as well as verify some of your the exotic settings specifically dealing with USB and inspect your PCI settings. See if you can get them to behave in an "older" fashion. Given the newness of the BIOS, it has got to be something specific to the BIOS itself. Did you turn off your TCM? It may be something specifically dealing with "Trusted Computing" that is giving the installer heart-burn.

Sorry, ignore above.. I did not read your post as close as I should have ... See if you can get the option for both uEFI as well as Legacy booting enabled. And I would dig really deep in there and look for oddball stuff with trusted computing that is outside of what the main enable/disable of the TPC module is set to.

yeah, what is happening here i think is you are not setting your uefi options the same. so windows might be installed legacy then you are setting linux to boot to uefi and it is causing the os not to boot. i dont know if there is an option to check but when i ran into something similar, that was the issue.

Could see your lsblk -f and gdisk info?

gdisk /dev/sda

?
p

How am I supposed to provide you this information if I can't even boot into Linux in the first place?

OK. Can you boot a Linux live environment, i.e. boot the USB to "try the OS" without installing?
We need as much of the error messages you can get. "CPU not responding" sounds serious though.
When you say "This issue also extends to drives that have the OS already installed on them", what exactly are you refering to? What OS (other than WIndows)?

Also important: What sort of distros have you tried? Have you tried rolling release / bleeding edge stuff, too (Fedora, Arch)?
How old is the hardware?