The current Linux distributions (SUSE, Fedora/Red Hat, Debian with "Etch") use the FHS (Filesystem Heirarchy Specification), and ship the same software (2.6 kernel, X.org etc.) so are mostly similar.
Variations occur for specific technologies where the implementation can differ by distribution. For example, service management is not standardized between distributions. Unfortunately, you do have to use a couple of distros to be familiar with those areas - if you've used Debian and Fedora you'll be fine.
I don't actually know whether Slackware complies with the FHS.
Edit: amended to answer the question on learning variations.
Last edited by hob; 08-09-2006 at 10:02 AM.
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