Is your CD-ROM drive
mounted when you do this? That would be the first reason that it could not be accessed. It doesn't matter what letter you make it in Wine (although I like to use the same drive letter as my CD-ROM under Windows, since that way the *.ini or *.cfg or Registry files for the game are the same as in Windows, so that they're interchangeable); the problem is that the drive is not available to Wine at all.
If you mount the drive manually using a short command such as
mount /mnt/cdrom, that means that your CD-ROM drive is listed in
/etc/fstab, and if the settings need to be changed, you will need to edit that file (as root) to do so.
Of course, you could always mount it with a full command (even if it's listed in /etc/fstab), such as
mount -t iso9660 -o users,exec /dev/hdc /mnt/cdrom.
Basically, the three problems may be that you as a user do not have rights to mount the drive (which you need), you may not have rights to read the contents of the drive (which you obviously need), or you may not have rights to execute programs on the drive (which you also likely need).
So in general, what you want to do is unmount the drive if mounted, then open a file manager as root and first check the permissions on the mount point for the CD-ROM drive. It will be owned by root and the root group, but do "others" (that's you as a user) have read and execute permissions to this mount point? If not, enable those for the folder in question.
Then open up a text editor and open /etc/fstab. Post the line related to the CD-ROM drive here; I'm not going to guess what you need to change to enable user-level mounting of this drive.
And please calm down. This is not IRC or an SMS where you have to type quickly so that capitals, spaces and full stops fall by the wayside, and this is not such a serious problem that multiple ??? s are necessary. You post as if you're running around a room screaming, "Help me! Help me!" with your arms waving wildly. It's a little annoying. Calm down. If you were calm, you could read some of the help provided by Wine, both in the man pages (
man wine-- yes, there is one, who knew?), on the
Wine homepage, or on
Frank's Corner, which would have answered many of your questions already.