I am sending this out again in a different forum hoping I will get a better response.

Distro - Ubuntu 10.04 standard Gnome desktop
Problem - Left mouse button fails to work on MOST if not all applications such as Firefox web pages, games, Open Office Word, even KDE applications. You can close the window with the upper right hand X with the left mouse button but any other place in the application the mouse pointer turns to a hand shape when you click it but nothing happens
Attempts at resolution - replace mouse with known good mouse, try different users, and someone suggested that it was an accessibility problem. Someone from this Forum (hardware) suggested it was a GTK problem.
Results - The problem is happening for only one user (myself). 3 other users have no problem at all.
So it is not hardware related, but user related. I compared the Accessibility settings to a known good user but did not find anything. (I looked at the gui settings since I do not know which file to check at the command line). I have no idea how to check if the problem is in GTK because I do not even know what that is.
I think the problem happened when I mounted an external hard drive to add wallpaper but did not copy the wallpaper over to my home directory. I might have messed up the theme I was using so I reloaded the theme from a web sight. I have also auto mounted the drive at boot, but that did not fix the problem.
Being some what of a newbie, I do not know where to look.
Can someone please point me in the right direction.

It's the first time I hear of this problem, but we can try to figure it out by eliminating the working parts.

First we need to check if this problem is in the system or in your profile. Log out as user and log in into a text console. You can do this by pressing {Ctrl}-{Alt}-{F1} for example... F1-F6 are all valid text consoles.

Login with your name as sudoer (since you said you're using Ubuntu) and enter the following commands:

cd /home
sudo mv yourlogin_name yourlogin_name.bak
sudo mkdir yourlogin_name
sudo chmod 700 yourlogin_name
sudo chown yourlogin_name:yourlogin_name yourlogin_name

Now press {Ctrl}-{Alt}-{F7} to return to the graphical login screen. Sometimes {Ctrl}-{Alt}-{F8} is needed to do that.

Login with your login name and password. Now you're entering a new, clean profile with all default settings. Run a program affected by this mouse problem and test if the problem is still there. If it's gone, you may keep your profile as it is now, or if it's a system issue, undo your changes as follows:

Press {Ctrl}-{Alt}-{F1} for example... F1-F6 are all valid text consoles.

cd /home
sudo rmdir yourlogin_name
sudo mv yourlogin_name.bak yourlogin_name

Now press {Ctrl}-{Alt}-{F7} to return to the graphical login screen. Sometimes {Ctrl}-{Alt}-{F8} is needed to do that.



Succes.

Thank you sooooooo much for your info. I will try this out first chance I get and let all know.
Mike