I'm not sure why you want to change the MAC address of the interface, or what for. But I think you are saying that you can't connect to any website and you get the error "unknown host".
DNS servers are stored in /etc/resolv.conf in the format "nameserver [IP Address]", eg
Code:
nameserver 123.123.123.123
nameserver 213.213.213.213
nameserver 231.231.231.231
you can change them anytime, whether the interface is down or not.