Hi. Can someone tell me that there is a way to setup squid on a computer having one network interface card.

the number of nics you have is generally of no interest to squid. In fact, a normal server would only have one network connection for data traffic, as it is still a server, not a network device. Just follow standard documents.

This (one nic) is probably the normal way to set-up squid. The only exception I can think of is when you are trying to use squid to enforce some kind of security policy, and then two nics may be a safer way to go than one (depending on how the network is set up, and how you feel about belt and braces).

The usual answer to squid questions is 'read the conf file'. The options are well documented there, but that doesn't mean that you'll read it all in two minutes flat.

If you don't think that your thread has had a proper answer yet, you could consider reporting it and getting a mod to move it somewhere more appropriate than virtualisation (sorry, virtualization). Personally, I don't think it will get you that much more information, though.