If you want to edit equations that you want included in a text document, and your primary requirements are that the equations are comprehensible and look right, you should probably use the equation editor.
If, on the other hand, you want the equations to be evaluated, you will probably have to use calc.
If your equations are, e.g., jpegs, included as graphics objects in existing documents then you will have to look at editing jpegs (or it may be better to start again with your own equations).
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