I recently lost sound on my computer and decided it was a failure of the sound circuit on the motherboard. Accordingly I installed a Trust sound card to replace it, and all is back to normal. Except for emulation.

Wine is still silent, and when I run the Wine configuration program, and select Audio, I get a pop-up message:
Found driver in registry that is not available!
Remove "pulse" from registry?
Then, whether I select ALSA or OSS, the sound test is always failed.

Sound is also missing from the FBZX Spectrum emulator.

Does any one have any suggestions?

If no one gives you better solution, I would suggest to save somewhere folder "/.wine" with all its programs, and install wine again. If you will have sound in the NEW wine then you can compare two win registry (old and new), and will be able to change driver information in old one.

If in new installed wine you won't hear anything, just rename OLD wine back.

I did it, but for test purposes.

This is evidently not a Wine thing, for sound is back in Wine. I've just run the configuration to check, and PulseAudio is now listed as available and selected. On the other hand, there's still no sound in the Spectrum emulator. Obviously the curse of PulseAudio has struck again!