The person above basically said it all, but if you need a second opinion:
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Originally Posted by levi_s
So. it is my understanding that Corel Painter, will under no circumstances, run in wine.
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Didn't try it personally. However, it's rated as "Garbage" on all the instances I found at the wine database. We can assume that it will not work at the current state of wine.
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it is also, my understanding that you can install a complete copy of Windows XP inside of Wine.
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No. Wine runs
instead of windows. It can't run windows. It's work is to substitute windows, so windows programs can run on top of wine instead of running on top of windows.
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If this is true, can you then install Painter inside the Windows environment that is inside Wine??
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No, however you can install windows inside a virtual machine. There's virtualbox and wmware as the other poster said. There's also bochs. I'd recommend to start checking virtualbox.