You need to tell us the whole story instead of coming up with bits and pieces of information one by one. Your original message left out that you were using putty with x11 forwarding on windows, that there were programs (xclock) that could be executed without problems, and the precise error message.
We still don't know what X server you using on which version of Windows, whether you ran xclock with the same display setting or a different one, whether you can run xclock in the exact same putty window where issetup fails and probably many other relevant details. To get gelp, you need to provide the background and all the details.
Googling for the error message yields a number of results which may or may not match your case, but only you can tell, because only you have the full information. Here is a possible solution for your problem,
assuming that you use a specific version of the cygwin x server and a specific configuration:
http://qandasys.info/putty-cygwinx-a...ction-refused/.