You need to give some info about your box, like kernel number and video card info. My first guess without any info is to install a non-vanilla kernel, like a ck (Con Kolivas) kernel. Ck kernels have patches that improve gaming performance and desktop responsiveness. But I've heard many people complain about poor Doom 3 performance on Linux. I've played the demo and you might just have to put the settings on low.
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