Memory configuration may be similar, but usage will almost never be on disparate systems.
Cache usage is usually not an issue - by design memory management will attempt to use otherwise idle memory to improve (disk) I/O response times. Slab usage and page table growth on the other hand should really get your attention. Somebody is misbehaving - I'd guess lots (and I mean *lots*) of probably small memory requests. Run these - and use [code] tags as advised when posting (also go back and edit your initial post)
Code:
sudo slabtop -o
sudo slabtop -o -s c
Edit: forgot to ask: what distro, what kernel version ?.