Two other ways to try and configure mouse acceleration are "xinput" and "xset"
https://wiki.archlinux.org/index.php/Mouse_acceleration
I haven't messed with mouse acceleration settings, but I have generally had a lot of success with using xinput to modify settings for mouse, wacom stylus, and touchscreen input. I have only used xset for things like turning off screen blanking or manually screen blanking.
Note that xinput settings do not "persist". You can create a bash script to run various xinput settings and set that script to automatically run on session startup. (I'm not a GNOME user, so I don't know exactly where you do that.) It'll look something like:
Code:
#!/bin/sh
sleep 5
xinput set-button-map "Logitech Unifying Device. Wireless PID:400a" 1 2 3 4 5 0 0 6 7
xinput set-prop "Serial Wacom Tablet FUJ02e5 stylus" "Wacom Rotation" 3
xinput set-prop "Serial Wacom Tablet FUJ02e5 stylus" "Wacom Tablet Area" 300, 250, 28708, 18080
xsetwacom set "Serial Wacom Tablet FUJ02e5 stylus" MapToOutput LVDS1
xsetwacom set "Serial Wacom Tablet FUJ02e5 eraser" MapToOutput LVDS1
I include a 5 second delay at the start just in case XFCE4 (in your case GNOME) is doing stuff in the first few seconds that might get confused if my xinput commands start firing off to early.
Your xinput commands will differ, of course.