Hi,
I don't know how mimedefang works, but you can use procmail to scan incoming mail through spamassassin. Procmail usually comes with sendmail in order to deliver mail to users mailboxes.
So for this seup to work, you need to add in /etc/procmailrc:
Code:
DROPPRIVS=yes
:0fw
| /usr/bin/spamc
See "Sitewide filtering"
here for details.
Regards