Depends really.
If you are using up2date or getting the RPM's to upgrade from your distro's mirrors, then it should be rather seemless, and the command would be (just an example):
rpm -
Uvh filename.rpm
To "Upgrade" an existing install. You can use that for new ones as well in case you aren't sure what's installed and what's not
If you are grabbing source however, you may need to tweak some (alot) of the configurations script (if there is one) to fit the needs of your system, alternatively, you can:
mv program program.old
And then install (if you don't know what I mean, you may wanna stick with RPM's until you get a grasp on source installs

).
Cool