LinuxQuestions.org - Deferred: Connection timed out with mail

We are running LDAP on one of the most current distro's of Redhat, and just this week we started having problems emailing to one specific domain. All the emails that we send to someone on this domain will bounce back with the message that it could not deliver the email and that you should not resend it because it will continue to try and send it for 5 days. If I type in mailq at the prompt, I have about 80 emails all waiting to send for the past three days or so. Here is a sample of some of the messages that I am seeing with the mailq command:

lB7L61Rn023334 7705 Fri Dec 7 14:06 <user@somecompany.com>
(reply: read error from mail.cascadewindows.com.)
<kpeek@cascadewindows.com>
lB6KYDWk002182 1590 Thu Dec 6 13:34 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<sbutigan@cascadewindows.com>
lB3IeMQJ000471 194094 Mon Dec 3 11:40 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<sbutigan@cascadewindows.com>
lB3FsA2K028513 674 Mon Dec 3 08:54 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<sbutigan@cascadewindows.com>
lB3FSDq5027683 1055 Mon Dec 3 08:28 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<jpeichoto@cascadewindows.com>
lB3G3qcE028896 87429 Mon Dec 3 09:03 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<jpeichoto@cascadewindows.com>
lB3FXw6m027861 87429 Mon Dec 3 08:33 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<eferreira@cascadewindows.com>
lB3IuQMQ000863 409814 Mon Dec 3 11:56 <user@somecompany.com>
(Deferred: Connection timed out with mail.cascadewindows.com.)
<jpeichoto@cascadewindows.com>

Some of them say read error, others say connection timed out. Any idea on what may be causing this?

Thanks!!