Your question is a bit cryptic, but in short: routers don't forward layer 2 frames. Routers forward layer 3 packets, by removing the layer 2 frame information and wrapping it up again in a new frame on the other side.
Systems on the same layer 2 link (ethernet network usually) typically know the ip address of the host (or gateway) they want to communicate with, and then they have to figure out the layer 2 address (MAC) through ARP.
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