/dev/ttyS1 is the second RS-232 (serial) port on your machine, if you have a serial joystick connected to this port then all should go well.
I apologise if I sound a bit patronising here, but have you checked that: Your joystick is a serial type and is supported by Linux, that it is connected to the second serial port - the first is ttyS0, and that there is no other reason why you cannot use the serial ports - permissions for example.
Hope this helps!
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