until you get a better reply....
skype attempts to use the default sound which is unlikely to be USB but some internal card.
quite a few settings for most distros stop USB from grabbing index=0 which is actually what skype wants.
have a look at /etc/modprobe.d/alsa-base.conf
Quote:
options snd-usb-audio index=-2
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As a suggestion plug in and leave in your webcam, use root powers to edit that quote to change index=-2 to 0
full reboot
----there are other ways of restarting alsa but lets keep it simple first
open a terminal and type alsamixer and press enter and you should see your usb device.
now skype should find it too
good luck