Your desktop mixer is always accessing the card, I don't know which RedHat is using, gmix or aRts or whatnot, but if you kill whatever is using the card it will let you unload the modules.
Offhand, I also have a cmpci based card, the CMI 8738 chipset, and my card would occasionally stall for 30-90 seconds, I disable KDE's aRts sound server, and the problem went away.
Cheers
Finegan
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