Basic scanning with Epson products generally works with the open source sane drivers, but access to their other built-in features, particularly their full range of scanning resolutions, generally requires their proprietary iscan driver.
Unfortunately iscan has a pretty primitive interface (unless they've done anything to upgrade it since the last time I looked), so don't expect much. The third-party vuescan may give you a more satisfying experience, if you're willing to pay for it.
See the links in my signature.
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