Take a look at the "sysrq.txt" file, it should be included in the documentation for your kernel source (check the /usr/src/linux/Documentation directory.) It explains which key combinations can be used for emergency shutdowns, syncing of drives, etc.
But like the top of the file states, if it is truly locked up, there may not be anything you can do (other than use a journaling file system to gracefully recover from a hard shutdown.)
Speck
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