Mandrake can have some issues on some hardware. Also has a problem with the KDE sound server which will lock it up - so try turning off the KDE sound server in the KDE control panel. Also it can have some issues with USB flash drives on some machines, while it behaves perfectly on others. Bit of a pain.
I've cured the USB flash drive problem on this box by compiling a nice new 2.6.7 generic kernel, but you don't want to do that if you don't have to just yet.
Try the KDE sound server for a start!
Why is this so? Mandrake tend to be more cutting edge, and 10 is the first to use the 2.6 kernel in the MDK range, so there are often problems with MDK due to the fact it does use the latest stuff. 10.1 will be more stable, I'd say, but 10 is very stable on most systems. Just not all