I just started learning about LXDE and want to give it a try but am wondering if anyone has an opinion of the best distro to use LXDE with. I just want to give it a try so am looking for a good way to get started with it.

It's just a DE, isn't it? Any distro should be good. I used LXDE with Debian. Was good.

I second that, I did a minimal debian install and chose LXDE. It worked great in my Toshiba 70000CT with 160MB RAM/4GB HD.

The new Knoppix has LXDE and I like it!

I'm new to Linux but it seemed when i started KDE was the big desktop, Gnome #2, then Xfce was #3 but getting much more popular but has that changed.
It seems with the changes to KDE it's not as popular as it once was and many are switching to Gnome and that maybe Xfce has grown some but LXDE is becoming very popular and maybe is #3 now. I'm just wondering if this is what's happening now.
I have had suggestions of Debian and Xubuntu elsewhere. I'll also look at Knoppix.

Vector Linux comes with LXDE as an option. I try others but always come back to Vector!

Another with LXDE would be SaxenOS 2009-beta2.

KDE and Gnome aren't bad they just became too big. That is why there came smaller alternatives. And LXDE is great.

There are many much more - yoe can have distros with:
Enlightenment, Fluxbox, JWM, IceWM, Openbox, FVWM, Fvwm95,WMaker, ..
And if you look closer you will see even those have their pros and it depends much more how they are installed than on everything else.
E.g. JWM: DSL and TARTUGA come with it, SliTaz used to come with it and it seems a bit....
but if you look at Puppy, which uses it as well you see even JWM is great.
Never the less I thing Knoppix with LXDE ia a very good choice.