Thanks for your help @ferrari!
I can tell you that running simple-scan in debug mode, appear clear what it run: xdg-email --attach "path/to/name/file"
Running the same command via terminal, do not get any results.
Simply, seem that LXDE have not a preferred email app to run.
But looking into preferred-default-app, Thunderbird appears and seem correctly configured.
It's seem a Ubuntu/LXDE bug:
https://bugs.launchpad.net/ubuntu/+s...s/+bug/1540399
Changing as you suggest Exec=thunderbird %u to Exec=thunderbird %f %u works great if you want to send by left-click mouse, but no by simple-scan.
I've open an issue on github xdg-utils-ng:
https://github.com/matthewbauer/xdg-utils-ng/issues/2
many thanks!