You still should use rpm for removing the devel packages, some are important and some are needed if you are building your own packages. The kernel-devel rpm packages are useful for many so it would be a good idea not to remove this package.
In general it is OK to remove the devel packages and their dependent devel rpm packages, one can use either yum or rpm for this, just be careful not to remove any wanted/ needed packages. Example yum command;
yum remove foo-devel.i386
Yes, if you attempt to remove a package or packages that has dependencies it will not remove the package and will list what is dependent on the package(s).
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