I am by no means experienced with audio problems but since you haven't received any input in 10 days I might as well throw out a couple of thoughts.
I guess you'll first want to find out what sound system you are using ... probably alsa or pulseaudio.
You may want try the respective other.
If you are using pulseaudio there is an option to kill it (pulseaudio -k) and then restart it. Would be interesting to find out if that helps at all, rather than having to do a full reboot.
There will certainly also be a way to restart alsa, this is something you could search the web for.
See if you can find any info in your system logs. I have no experience with fedora, but typically you want to search the /var/log/ folder.
Check what hardware you are using by running
In my case it looks like this:
Code:
lspci | grep Audio
00:03.0 Audio device: Intel Corporation Haswell-ULT HD Audio Controller (rev 09)
00:1b.0 Audio device: Intel Corporation 8 Series HD Audio Controller (rev 04)
This gives you something you can put into search engines. E.g. search "00:03.0 Audio problems linux" (obviously replacing the 00:03.0 part with what your lspci said...)
Another idea: Run top in a console when starting skype and see if there is any process coming up that hogs all your memory.